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primary rat hippocampal neuron cultures  (Charles River Laboratories)

 
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    Charles River Laboratories primary rat hippocampal neuron cultures
    Effects of 12-mer-19 (19) and 12-mer-NAc (NAc) on the function excitatory synapses (A-C) and inhibitory synapses (D-E). A) Traces of mEPSC recordings from primary rat <t>hippocampal</t> neurons. B) Treatment of 12-mer-19 resulted in a reduction in mEPSC frequency. There was no significant change between control (Con) and 12-mer-NAc-treated groups. C) There was a significant decrease in EPSC amplitude between 12-mer-19 and control groups but not between 12-mer-19 and 12-mer-NAc groups. D) Traces of mIPSC recordings from primary rat hippocampal neurons. E and F) No significant difference was observed among all groups in the frequency (E) and amplitude (F) of mIPSC. ****p<0.0001 or *p=0.01 by one-way ANOVA with posthoc Bonferroni’s multiple comparison tests. N=21-24 cells from 6 independent experiments for mEPSC. N=19-22 cells from 3 independent experiments for mIPSC. Error bars represent SEM.
    Primary Rat Hippocampal Neuron Cultures, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/primary rat hippocampal neuron cultures/product/Charles River Laboratories
    Average 86 stars, based on 1 article reviews
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    1) Product Images from "A synthetic HS structure selectively impairs the morphology and function of excitatory synapse by disrupting neurexin1 interactions"

    Article Title: A synthetic HS structure selectively impairs the morphology and function of excitatory synapse by disrupting neurexin1 interactions

    Journal: Glycobiology

    doi: 10.1093/glycob/cwaf039

    Effects of 12-mer-19 (19) and 12-mer-NAc (NAc) on the function excitatory synapses (A-C) and inhibitory synapses (D-E). A) Traces of mEPSC recordings from primary rat hippocampal neurons. B) Treatment of 12-mer-19 resulted in a reduction in mEPSC frequency. There was no significant change between control (Con) and 12-mer-NAc-treated groups. C) There was a significant decrease in EPSC amplitude between 12-mer-19 and control groups but not between 12-mer-19 and 12-mer-NAc groups. D) Traces of mIPSC recordings from primary rat hippocampal neurons. E and F) No significant difference was observed among all groups in the frequency (E) and amplitude (F) of mIPSC. ****p<0.0001 or *p=0.01 by one-way ANOVA with posthoc Bonferroni’s multiple comparison tests. N=21-24 cells from 6 independent experiments for mEPSC. N=19-22 cells from 3 independent experiments for mIPSC. Error bars represent SEM.
    Figure Legend Snippet: Effects of 12-mer-19 (19) and 12-mer-NAc (NAc) on the function excitatory synapses (A-C) and inhibitory synapses (D-E). A) Traces of mEPSC recordings from primary rat hippocampal neurons. B) Treatment of 12-mer-19 resulted in a reduction in mEPSC frequency. There was no significant change between control (Con) and 12-mer-NAc-treated groups. C) There was a significant decrease in EPSC amplitude between 12-mer-19 and control groups but not between 12-mer-19 and 12-mer-NAc groups. D) Traces of mIPSC recordings from primary rat hippocampal neurons. E and F) No significant difference was observed among all groups in the frequency (E) and amplitude (F) of mIPSC. ****p<0.0001 or *p=0.01 by one-way ANOVA with posthoc Bonferroni’s multiple comparison tests. N=21-24 cells from 6 independent experiments for mEPSC. N=19-22 cells from 3 independent experiments for mIPSC. Error bars represent SEM.

    Techniques Used: Control, Comparison



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    Effects of 12-mer-19 (19) and 12-mer-NAc (NAc) on the function excitatory synapses (A-C) and inhibitory synapses (D-E). A) Traces of mEPSC recordings from primary rat <t>hippocampal</t> neurons. B) Treatment of 12-mer-19 resulted in a reduction in mEPSC frequency. There was no significant change between control (Con) and 12-mer-NAc-treated groups. C) There was a significant decrease in EPSC amplitude between 12-mer-19 and control groups but not between 12-mer-19 and 12-mer-NAc groups. D) Traces of mIPSC recordings from primary rat hippocampal neurons. E and F) No significant difference was observed among all groups in the frequency (E) and amplitude (F) of mIPSC. ****p<0.0001 or *p=0.01 by one-way ANOVA with posthoc Bonferroni’s multiple comparison tests. N=21-24 cells from 6 independent experiments for mEPSC. N=19-22 cells from 3 independent experiments for mIPSC. Error bars represent SEM.
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    Effects of 12-mer-19 (19) and 12-mer-NAc (NAc) on the function excitatory synapses (A-C) and inhibitory synapses (D-E). A) Traces of mEPSC recordings from primary rat <t>hippocampal</t> neurons. B) Treatment of 12-mer-19 resulted in a reduction in mEPSC frequency. There was no significant change between control (Con) and 12-mer-NAc-treated groups. C) There was a significant decrease in EPSC amplitude between 12-mer-19 and control groups but not between 12-mer-19 and 12-mer-NAc groups. D) Traces of mIPSC recordings from primary rat hippocampal neurons. E and F) No significant difference was observed among all groups in the frequency (E) and amplitude (F) of mIPSC. ****p<0.0001 or *p=0.01 by one-way ANOVA with posthoc Bonferroni’s multiple comparison tests. N=21-24 cells from 6 independent experiments for mEPSC. N=19-22 cells from 3 independent experiments for mIPSC. Error bars represent SEM.
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    Image Search Results


    Effects of 12-mer-19 (19) and 12-mer-NAc (NAc) on the function excitatory synapses (A-C) and inhibitory synapses (D-E). A) Traces of mEPSC recordings from primary rat hippocampal neurons. B) Treatment of 12-mer-19 resulted in a reduction in mEPSC frequency. There was no significant change between control (Con) and 12-mer-NAc-treated groups. C) There was a significant decrease in EPSC amplitude between 12-mer-19 and control groups but not between 12-mer-19 and 12-mer-NAc groups. D) Traces of mIPSC recordings from primary rat hippocampal neurons. E and F) No significant difference was observed among all groups in the frequency (E) and amplitude (F) of mIPSC. ****p<0.0001 or *p=0.01 by one-way ANOVA with posthoc Bonferroni’s multiple comparison tests. N=21-24 cells from 6 independent experiments for mEPSC. N=19-22 cells from 3 independent experiments for mIPSC. Error bars represent SEM.

    Journal: Glycobiology

    Article Title: A synthetic HS structure selectively impairs the morphology and function of excitatory synapse by disrupting neurexin1 interactions

    doi: 10.1093/glycob/cwaf039

    Figure Lengend Snippet: Effects of 12-mer-19 (19) and 12-mer-NAc (NAc) on the function excitatory synapses (A-C) and inhibitory synapses (D-E). A) Traces of mEPSC recordings from primary rat hippocampal neurons. B) Treatment of 12-mer-19 resulted in a reduction in mEPSC frequency. There was no significant change between control (Con) and 12-mer-NAc-treated groups. C) There was a significant decrease in EPSC amplitude between 12-mer-19 and control groups but not between 12-mer-19 and 12-mer-NAc groups. D) Traces of mIPSC recordings from primary rat hippocampal neurons. E and F) No significant difference was observed among all groups in the frequency (E) and amplitude (F) of mIPSC. ****p<0.0001 or *p=0.01 by one-way ANOVA with posthoc Bonferroni’s multiple comparison tests. N=21-24 cells from 6 independent experiments for mEPSC. N=19-22 cells from 3 independent experiments for mIPSC. Error bars represent SEM.

    Article Snippet: Primary rat hippocampal neuron cultures were prepared from embryonic day 18 rat (Charles River, CD 001) using the Banker-style culture method ( Kaech and Banker 2006 ).

    Techniques: Control, Comparison